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100929-53-1 | DAMGO (acetate)

DAMGO (acetate) NLT 98%

SKU : MC501331

CAS Number : 100929-53-1

Molecular Formula : C28H39N5O8 | Molecular Weight : 573.64

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name DAMGO (acetate)
CAS Number 100929-53-1
MDL Number MFCD00133215
Molecular Formula C28H39N5O8
Molecular Weight 573.64
Introduction of 100929-53-1 :

DAMGO acetate is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1]. IC50 & Target: Kd: 3.46±0.84 nM (native μ-OPR)[1] In Vitro: DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. In native μ-OPR, the Kd value for DAMGO is 3.46± 0.84 nM (n=3). The chimeric receptor MMDD, in which the carboxy-terminal half of μ-OPR is replaced with the corresponding region of δ-OPR, exhibits an equivalent affinity (Kd=2.13±0.40 nM; n=3) to DAMGO compared with the native μ-OPR[1]. DAMGO is a selective μ-opioid peptide. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies. Regulation of neuronal response to CXCL12 is essential for shaping of developing and mature central nervous system (CNS). To establish whether DAMGO alter the effect of CXCL12 on neuronal survival, the ability of CXCL12 to protect neurons from N-methyl-d-aspartate (NMDA)-induced death is examined in the presence and absence of DAMGO. Cortical cultures are treated with DAMGO (1 and 10 μM). Neurons are subsequently exposed to NMDA (20 min) and/or CXCL12 (added 10 min before NMDA) in the absence of glia and then returned to the original culture dishes with the glial feeder layer. Neuronal death is evaluated after 24 h. DAMGO inhibits neuronal survival promoted by CXCL12[2].

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