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100929-99-5 | PAβN (dihydrochloride)

PAβN (dihydrochloride) NLT 98%

SKU : MC501334

CAS Number : 100929-99-5

Molecular Formula : C25H32Cl2N6O2 | Molecular Weight : 519.47

Synonyms : MC-207,110 dihydrochloride;Phe-Arg-β-naphthylamide dihydrochloride

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name PAβN (dihydrochloride)
CAS Number 100929-99-5
MDL Number MFCD00058046
Molecular Formula C25H32Cl2N6O2
Molecular Weight 519.47
Synonyms MC-207,110 dihydrochloride;Phe-Arg-β-naphthylamide dihydrochloride
Introduction of 100929-99-5 :

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. In Vitro: PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa[1]. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates[2]. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, and this additional mode of action should be considered when using PAβN as a control for efflux studies[3].

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