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101-20-2 | Triclocarban

Triclocarban NLT 98%

SKU : MC501458

CAS Number : 101-20-2

Molecular Formula : C13H9Cl3N2O | Molecular Weight : 315.58

Synonyms : 3,4,4′-Trichlorocarbanilide

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Triclocarban
CAS Number 101-20-2
MDL Number MFCD00013254
Molecular Formula C13H9Cl3N2O
Molecular Weight 315.58
Synonyms 3,4,4′-Trichlorocarbanilide
Introduction of 101-20-2 :

Triclocarban is an antimicrobial agent used in personal cleaning products. IC50 & Target: Bacterial[1] In Vitro: Triclocarban at 300 nM potentiates the cytotoxicity of 300 µM H2O2 in rat thymocytes. 300 nM triclocarban itself does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells[1]. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells[2]. In Vivo: Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM[1]. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring[3].

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