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1010100-07-8 | CC-885

CC-885 NLT 98%

SKU : MC501500

CAS Number : 1010100-07-8

Molecular Formula : C22H21ClN4O4 | Molecular Weight : 440.88

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name CC-885
CAS Number 1010100-07-8
Molecular Formula C22H21ClN4O4
Molecular Weight 440.88
Introduction of 1010100-07-8 :

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. IC50 & Target: CRBN[1]. In Vitro: Acute myeloblatlic leukemia (AML) cell lines, human liver epithelial cell line (THLE-2) and human peripheral blood mononuclear cells (PBMC) are treated with varying concentrations of CC-885, with IC50s of 10×-6-1 μM. The effect of CC-885 on cell proliferation in AML cell lines, THLE-2 and human PBMC is more powerful than Lenalidomide and Pomalidomide with IC50s>10 μM. To address whether the cereblon-dependent degradation of GSPT1 is responsible for the cytotoxic effects of CC-885, a GSPT1 mutant that retains its normal function, but loses CC-885-dependent cereblon binding, is used to distinguish the role of GSPT1 from that of other substrates. CC-885 is tested in 293T HEK cells stably expressing the CC-885-sensitive or -resistant GSPT1 variants. Overexpression of a resistant variant GSPT1Δ(1–138)/(G575N) completely abrogate the CC-885-induced anti-proliferation, whereas overexpression of a CC-885-sensitive variant GSPT1Δ(1-138) only confer partial protection. Similar results are obtained in AML cell lines[1].

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