GSK369796 Dihydrochloride NLT 98%

GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM. IC50 & Target: IC50: 7.5 μM (hERG potassium ion channel)^[1] In Vitro: In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC₅₀s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC₅₀ of 7.5±0.8 μM^[1]. In Vivo: In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED₅₀ and ED₉₀ of 2.8 and 4.7 mg/kg, respectively^[1].