1010411-21-8

GSK369796 Dihydrochloride NLT 98%

Name: GSK369796 Dihydrochloride
Brand: Molcore
SKU: MC501519
Rating: 96 (42 reviews)

Product Number : MC501519

CAS Number : 1010411-21-8

Molecular Formula : C20H23Cl2N3O | Molecular Weight : 392.32

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Specifications
Product Details

Purity	NLT 98%
Storage	at 20ºC 2 years
MolCore specializes in manufacturing high-purity CAS No.1010411-21-8, GSK369796 Dihydrochloride with the molecular formula C20H23Cl2N3O and molecular weight 392.32 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems.

* The above information is for reference only.

Chemical Name	GSK369796 Dihydrochloride
CAS Number	1010411-21-8
MDL Number	MFCD22566645
Molecular Formula	C20H23Cl2N3O
Molecular Weight	392.32

Introduction of 1010411-21-8 :

GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM. IC50 & Target: IC50: 7.5 μM (hERG potassium ion channel)^[1] In Vitro: In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC₅₀s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC₅₀ of 7.5±0.8 μM^[1]. In Vivo: In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED₅₀ and ED₉₀ of 2.8 and 4.7 mg/kg, respectively^[1].