SKU : MC501519
CAS Number : 1010411-21-8
Molecular Formula : C20H23Cl2N3O | Molecular Weight : 392.32
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | GSK369796 Dihydrochloride |
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CAS Number | 1010411-21-8 |
MDL Number | MFCD22566645 |
Molecular Formula | C20H23Cl2N3O |
Molecular Weight | 392.32 |
GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM. IC50 & Target: IC50: 7.5 μM (hERG potassium ion channel)[1] In Vitro: In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC50 of 7.5±0.8 μM[1]. In Vivo: In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED50 and ED90 of 2.8 and 4.7 mg/kg, respectively[1].
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