Microcystin-LR NLT 98%
Product Number : MC501522
CAS Number : 101043-37-2
Molecular Formula : C49H74N10O12 | Molecular Weight : 995.17
Synonyms : Cyanoginosin-LR;MC-LR;Toxin T 17 (Microcystis aeruginosa)
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Microcystin-LR |
|---|---|
| CAS Number | 101043-37-2 |
| MDL Number | MFCD00871766 |
| Molecular Formula | C49H74N10O12 |
| Molecular Weight | 995.17 |
| Synonyms | Cyanoginosin-LR;MC-LR;Toxin T 17 (Microcystis aeruginosa) |
Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. IC50 & Target: IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1]. In Vitro: Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].
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