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1012104-68-5 | IRAK inhibitor 4

IRAK inhibitor 4 NLT 98%

SKU : MC501663

CAS Number : 1012104-68-5

Molecular Formula : C33H35F3N6O3 | Molecular Weight : 620.66

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name IRAK inhibitor 4
CAS Number 1012104-68-5
MDL Number MFCD22124483
Molecular Formula C33H35F3N6O3
Molecular Weight 620.66
Introduction of 1012104-68-5 :

IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor. In Vitro: Lack of IRAK-4 impairs the production of proinflammatory mediators by macrophages and DCs in response to M. bovis and M. tuberculosis. IRAK-4-/- cells stimulated with E. coli LPS display delayed activation kinetics of all signaling proteins analyzed, and exhibit dramatically reduced p65 phosphorylation[1]. IRAK1/4 (20 μM) has an inhibitory effect on LPS mediated IL-6 production. IRAK1/4 inhibitor do not decrease p38 phosphorylation in AMs. Combination of IRAK1/4 and Rip2 inhibitors inhibits TLR2-mediated cytokine production in sarcoidosis PBMCs and AMs[2]. IRAK4 is overexpressed and activated in T-ALL. IRAK4 mRNA level is elevated in T-ALL cells from patients compared with the levels detected in thymic T cells or T cells from peripheral blood[3]. In Vivo: IRAK-4-/- mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+ or IRAK-4+/- mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection[1]. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo[3].

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