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10129-56-3 | PETCM


SKU : MC501710

CAS Number : 10129-56-3

Molecular Formula : C8H8Cl3NO | Molecular Weight : 240.51

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name PETCM
CAS Number 10129-56-3
MDL Number MFCD00177920
Molecular Formula C8H8Cl3NO
Molecular Weight 240.51
Introduction of 10129-56-3 :

PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells[1][2]. IC50 & Target: IC50: caspase-3[1] In Vitro: PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP[1].
PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM[1].
PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells[1].

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