Simvastatin (sodium) NLT 98%
Product Number : MC501734
CAS Number : 101314-97-0
Molecular Formula : C25H39NaO6 | Molecular Weight : 458.56
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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* The above information is for reference only.
| Chemical Name | Simvastatin (sodium) |
|---|---|
| CAS Number | 101314-97-0 |
| MDL Number | MFCD04974206 |
| Molecular Formula | C25H39NaO6 |
| Molecular Weight | 458.56 |
Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2]. In Vitro: Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1].
Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1].
In Vivo: Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1].
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