Ro18-5362 NLT 98%
Product Number : MC501787
CAS Number : 101387-97-7
Molecular Formula : C22H25N3O2S | Molecular Weight : 395.52
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.101387-97-7, Ro18-5362 with the molecular formula C22H25N3O2S and molecular weight 395.52 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | Ro18-5362 |
|---|---|
| CAS Number | 101387-97-7 |
| Molecular Formula | C22H25N3O2S |
| Molecular Weight | 395.52 |
Ro18-5362 is the less active prodrug of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation. In Vitro: Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation[1]. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H++K+)-ATPase, decreasing enzymatic activity with an apparent Ki of 0.1 μM[2].
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