EZ-482 NLT 98%
SKU : MC502004
CAS Number : 1016456-76-0
Molecular Formula : C23H19ClN4O5S | Molecular Weight : 498.94
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | EZ-482 |
|---|---|
| CAS Number | 1016456-76-0 |
| Molecular Formula | C23H19ClN4O5S |
| Molecular Weight | 498.94 |
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1]. IC50 & Target: Kd: 5-10 μM (apoE3 and apoE4)[1] In Vitro: EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265[1].
EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner[1].
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