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1016456-76-0 | EZ-482

EZ-482 NLT 98%

SKU : MC502004

CAS Number : 1016456-76-0

Molecular Formula : C23H19ClN4O5S | Molecular Weight : 498.94

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name EZ-482
CAS Number 1016456-76-0
Molecular Formula C23H19ClN4O5S
Molecular Weight 498.94
Introduction of 1016456-76-0 :

EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1]. IC50 & Target: Kd: 5-10 μM (apoE3 and apoE4)[1] In Vitro: EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265[1].
EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner[1].

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