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1016543-77-3 | S516

S516 NLT 98%

SKU : MC502022

CAS Number : 1016543-77-3

Molecular Formula : C21H19N5O4S | Molecular Weight : 437.47

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Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.
Chemical Name S516
CAS Number 1016543-77-3
Molecular Formula C21H19N5O4S
Molecular Weight 437.47
Introduction of 1016543-77-3 :

S516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity[1]. IC50 & Target: IC50: 4.29 μM (tubulin polymerization)[1] In Vitro: S516 has potent cytotoxicity with IC50s of 4.8 nM, 42.8 nM and 24.9 nM for HL-60, HCT116 and HCT15 cells, respectively[1].
S516 (Compound 22; 30 nM; 16 hours; HL60 cells) treatmemt causes significant arrest of cells at the G2/M phase, resulting in apoptosis with concomitant loss of G0/G1 phase[1]. In Vivo: S516 (Compound 22; 5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) in human LX-1 lung cancer and CX-1 colon cancer mouse xenografts[1].

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