Thienopyridone NLT 98%
Product Number : MC502185
CAS Number : 1018454-97-1
Molecular Formula : C7H5NOS | Molecular Weight : 151.19
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.1018454-97-1, Thienopyridone with the molecular formula C7H5NOS and molecular weight 151.19 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | Thienopyridone |
|---|---|
| CAS Number | 1018454-97-1 |
| Molecular Formula | C7H5NOS |
| Molecular Weight | 151.19 |
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects[1]. IC50 & Target: IC50: 173 nM (PRL-1), 277 nM (PRL-2) and 128 nM (PRL-3)[1] In Vitro: Thienopyridone shows significant inhibition of tumor cell anchorage-independent growth in soft agar. The EC50 values of the Thienopyridone are 3.29 μM and 3.05 μM for RKO and HT-29 cells, respectively[1].
Thienopyridone (1-75 μM; 24 hours; HeLa cells) treatment shows a dose-dependent down-regulation of total p130Cas in HeLa cells. Thienopyridone induces p130Cas and FAK cleavage leads to caspase-mediated cell apoptosis. Thienopyridone induces the cleavage of PARP and caspase-8[1].
Thienopyridone (3.75-30 μM; 24 hours) significantly suppresses HUVEC migration but not proliferation[1].
© Copyright 2015-2025 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.