MDR-1339 NLT 98%
Product Number : MC502234
CAS Number : 1018946-38-7
Molecular Formula : C20H22O4 | Molecular Weight : 326.39
Synonyms : DWK-1339
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | MDR-1339 |
|---|---|
| CAS Number | 1018946-38-7 |
| MDL Number | MFCD22665705 |
| Molecular Formula | C20H22O4 |
| Molecular Weight | 326.39 |
| Synonyms | DWK-1339 |
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer's disease. IC50 & Target: Amyloid-β[1] In Vitro: MDR-1339 is an Aβ-aggregation inhibitor, and shows no significant inhibition a panel of CYP isozymes, while it slightly inhibits CYP2C8 (IC50, 31.4 μM). MDR-1339 (3.1-50 μM) dose-dependently blocks the formation of Aβ aggregates, and disaggregates Aβ fibrils. MDR-1339 (1.5-10 μM) also protects cells from this Aβ-induced toxicity[1]. In Vivo: MDR-1339 (0.1-10 mg/kg, p.o.) dose-dependently restores the passive avoidance responses in mice models of Alzheimer's disease (AD), with an ED50 of 0.19 mg/kg. MDR-1339 (30 and 100 mg/kg, p.o. daily for 8 weeks) significantly improves spontaneous alternation, and reduces the Aβ1-40 and Aβ1-42 levels in APP/PS1 mice[1].
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