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Introduction of 102013-72-9 :
m-PEG8-CH2COOH is a PEG--based PROTAC linker can be used in the synthesis of PROTACs. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.