Gardiquimod NLT 98%
SKU : MC502415
CAS Number : 1020412-43-4
Molecular Formula : C17H23N5O | Molecular Weight : 313.40
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Gardiquimod |
|---|---|
| CAS Number | 1020412-43-4 |
| Molecular Formula | C17H23N5O |
| Molecular Weight | 313.40 |
Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1][2]. IC50 & Target: TLR7, HIV-1 reverse transcriptase[1] In Vitro: Gardiquimod (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase[1]. In Vivo: Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells[2].
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