Pseudoprotodioscin NLT 98%
SKU : MC502480
CAS Number : 102115-79-7
Molecular Formula : C51H82O21 | Molecular Weight : 1031.18
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Pseudoprotodioscin |
|---|---|
| CAS Number | 102115-79-7 |
| MDL Number | MFCD04039839 |
| Molecular Formula | C51H82O21 |
| Molecular Weight | 1031.18 |
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1]. In Vitro: In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].
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