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102120-99-0 | (Rac)-Rotigotine (hydrochloride)

(Rac)-Rotigotine (hydrochloride) NLT 98%

SKU : MC502489

CAS Number : 102120-99-0

Molecular Formula : C19H26ClNOS | Molecular Weight : 351.93

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name (Rac)-Rotigotine (hydrochloride)
CAS Number 102120-99-0
MDL Number MFCD12911792
Molecular Formula C19H26ClNOS
Molecular Weight 351.93
Introduction of 102120-99-0 :

(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. IC50 & Target: Ki: Dopamine receptor; 5-HT receptor[1][2] In Vitro: Rotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7)[1].
Rotigotine (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4].

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