SKU : MC502523
CAS Number : 1021497-97-1
Molecular Formula : C20H18BrN3O3S | Molecular Weight : 460.34
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | KR-33493 |
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CAS Number | 1021497-97-1 |
Molecular Formula | C20H18BrN3O3S |
Molecular Weight | 460.34 |
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1). IC50 & Target: FAF1[1] In Vivo: Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics[1].
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