SKU : MC502584
CAS Number : 102212-26-0
Molecular Formula : C12H12N2O | Molecular Weight : 200.24
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | ARN2966 |
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CAS Number | 102212-26-0 |
Molecular Formula | C12H12N2O |
Molecular Weight | 200.24 |
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. IC50 value: Target: Aβ This potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.
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