SKU : MC502664
CAS Number : 1023650-66-9
Molecular Formula : C24H22ClN3O2 | Molecular Weight : 419.90
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | PF-3882845 |
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CAS Number | 1023650-66-9 |
Molecular Formula | C24H22ClN3O2 |
Molecular Weight | 419.90 |
PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM[1]. IC50 & Target: IC50: 2.7 nM (mineralocorticoid receptor), 310 nM (progesterone receptor)[1] In Vivo: PF-3882845 reduces blood pressure, decreases urinary albumin, and protects kidney in Dahl SS rat[1].
PF-3882845 exhibits moderate oral bioavailability (F 86%) following oral administration (2 mg/kg) in male Sprague-Dawley rats[1].
PF-3882845 exhibits terminal elimination half-lives (T1/2 1.7 h) due to high plasma clearance (CL 9.8 mL/min/kg) combined with large volumes of distribution (Vdss 1.4 mL/kg respectively) following intravenous administration (2 mg/kg) in male Sprague-Dawley rats[1].
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