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102396-24-7 | Jasplakinolide

Jasplakinolide NLT 98%

SKU : MC502687

CAS Number : 102396-24-7

Molecular Formula : C36H45BrN4O6 | Molecular Weight : 709.67

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Jasplakinolide
CAS Number 102396-24-7
MDL Number MFCD00467745
Molecular Formula C36H45BrN4O6
Molecular Weight 709.67
Introduction of 102396-24-7 :

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2]. In Vitro: Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

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