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Introduction of 1024448-59-6 :
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM. IC50 & Target: EC50: 0.77 μM (hTRPV4), 4.0 μM (mTRPV4), 4.1 μM (rTRPV4) .