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1026134-63-3 | Nelonicline

Nelonicline NLT 98%

SKU : MC502812

CAS Number : 1026134-63-3

Molecular Formula : C17H19N3OS | Molecular Weight : 313.42

Synonyms : ABT-126

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Nelonicline
CAS Number 1026134-63-3
Molecular Formula C17H19N3OS
Molecular Weight 313.42
Synonyms ABT-126
Introduction of 1026134-63-3 :

Nelonicline (ABT-126) is a selective neuronal nicotinic receptor agonist. IC50 & Target: Neuronal nicotinic receptor[1] In Vivo: The 0.03 mg/kg dose Nelonicline (ABT-126) has no significant effect on LIDs. Nelonicline at 0.10 mg/kg reduces LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. The effect of Nelonicline (1.0 mg/kg) is also tested for its ability to reduce LIDs at a higher dose of L-dopa (15 mg/kg)/carbidopa (3.75 mg/kg). The higher dose of L-dopa leads to greater LID scores in vehicle treated monkeys. Nelonicline treatment reduces LIDs by 70%, after the morning dose of L-dopa and 60% after the aftemoon dose. The effect of Nelonicline is most pronounced during the latter weeks, possibly because of a greater decline with continued drug treatment. A washout is in progress to determine if LIDs return to vehicle-treated levels after Nelonicline discontinuation. There is no effect of the drug on Parkinsonism or cognitive ability. Overall, these data indicate that Nelonicline would be useful as an antidyskinetic drug in Parkinson's disease[1].

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