SKU : MC502812
CAS Number : 1026134-63-3
Molecular Formula : C17H19N3OS | Molecular Weight : 313.42
Synonyms : ABT-126
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
Chemical Name | Nelonicline |
---|---|
CAS Number | 1026134-63-3 |
Molecular Formula | C17H19N3OS |
Molecular Weight | 313.42 |
Synonyms | ABT-126 |
Nelonicline (ABT-126) is a selective neuronal nicotinic receptor agonist. IC50 & Target: Neuronal nicotinic receptor[1] In Vivo: The 0.03 mg/kg dose Nelonicline (ABT-126) has no significant effect on LIDs. Nelonicline at 0.10 mg/kg reduces LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. The effect of Nelonicline (1.0 mg/kg) is also tested for its ability to reduce LIDs at a higher dose of L-dopa (15 mg/kg)/carbidopa (3.75 mg/kg). The higher dose of L-dopa leads to greater LID scores in vehicle treated monkeys. Nelonicline treatment reduces LIDs by 70%, after the morning dose of L-dopa and 60% after the aftemoon dose. The effect of Nelonicline is most pronounced during the latter weeks, possibly because of a greater decline with continued drug treatment. A washout is in progress to determine if LIDs return to vehicle-treated levels after Nelonicline discontinuation. There is no effect of the drug on Parkinsonism or cognitive ability. Overall, these data indicate that Nelonicline would be useful as an antidyskinetic drug in Parkinson's disease[1].
© Copyright 2015-2023 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.