SKU : MC502880
CAS Number : 1026987-94-9
Molecular Formula : C23H40N2O9 | Molecular Weight : 488.57
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | DUPA(OtBu)-OH |
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CAS Number | 1026987-94-9 |
Molecular Formula | C23H40N2O9 |
Molecular Weight | 488.57 |
DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. In Vitro: DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent[1]. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells[2]. In Vivo: DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice[3].
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