SKU : MC503202
CAS Number : 103131-69-7
Molecular Formula : C56H85N17O11 | Molecular Weight : 1172.38
Synonyms : Kinetensin (human)
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Kinetensin |
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CAS Number | 103131-69-7 |
MDL Number | MFCD00167613 |
Molecular Formula | C56H85N17O11 |
Molecular Weight | 1172.38 |
Synonyms | Kinetensin (human) |
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. IC50 & Target: Neurotensin Receptor[1] In Vitro: The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2]. In Vivo: Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].
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