Leupeptin (hemisulfate) NLT 98%
SKU : MC503419
CAS Number : 103476-89-7
Molecular Formula : C20H38N6O4 | Molecular Weight : 426.55
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Leupeptin (hemisulfate) |
|---|---|
| CAS Number | 103476-89-7 |
| MDL Number | MFCD00081028 |
| Molecular Formula | C20H38N6O4 |
| Molecular Weight | 426.55 |
Leupeptin hemisulfate is a membrane-permeable thiolprotease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion[1]. Leupeptin hemisulfate also exhibits anti-inflammatory effect[2]. IC50 & Target: Cathepsin[1] In Vivo: Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2].
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