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103476-89-7 | Leupeptin (hemisulfate)

Leupeptin (hemisulfate) NLT 98%

SKU : MC503419

CAS Number : 103476-89-7

Molecular Formula : C20H38N6O4 | Molecular Weight : 426.55

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Leupeptin (hemisulfate)
CAS Number 103476-89-7
MDL Number MFCD00081028
Molecular Formula C20H38N6O4
Molecular Weight 426.55
Introduction of 103476-89-7 :

Leupeptin hemisulfate is a membrane-permeable thiolprotease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion[1]. Leupeptin hemisulfate also exhibits anti-inflammatory effect[2]. IC50 & Target: Cathepsin[1] In Vivo: Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2].

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