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1038395-65-1 | Tirbanibulin (dihydrochloride)

Tirbanibulin (dihydrochloride) NLT 98%

SKU : MC503590

CAS Number : 1038395-65-1

Molecular Formula : C26H30ClN3O3 | Molecular Weight : 467.99

Synonyms : KX2-391 (dihydrochloride);KX-01 (dihydrochloride)

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Tirbanibulin (dihydrochloride)
CAS Number 1038395-65-1
MDL Number MFCD22495233
Molecular Formula C26H30ClN3O3
Molecular Weight 467.99
Synonyms KX2-391 (dihydrochloride);KX-01 (dihydrochloride)
Introduction of 1038395-65-1 :

Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. IC50 & Target: GI50: 9 nM (Src HuH7), 13 nM (Src PLC/PRF/5), 26 nM (Src Hep3B), 60 nM (Src HepG2) In Vitro: Tirbanibulin (KX2-391) is a Src inhibitor that is directed to the Src substrate pocket. KX2-391 shows steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines[1]. Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin (KX2-391) is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively[2]. In Vivo: Orally administered Tirbanibulin (KX2-391) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer[2].

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