SKU : MC503593
CAS Number : 1038410-88-6
Molecular Formula : C25H32N2O2S | Molecular Weight : 424.60
Synonyms : K201
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | JTV-519 |
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CAS Number | 1038410-88-6 |
MDL Number | MFCD00935784 |
Molecular Formula | C25H32N2O2S |
Molecular Weight | 424.60 |
Synonyms | K201 |
JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2]. In Vitro: JTV-519 (K201) inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201[2]. In Vivo: JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3].
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