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1038410-88-6 | JTV-519

JTV-519 NLT 98%

SKU : MC503593

CAS Number : 1038410-88-6

Molecular Formula : C25H32N2O2S | Molecular Weight : 424.60

Synonyms : K201

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name JTV-519
CAS Number 1038410-88-6
MDL Number MFCD00935784
Molecular Formula C25H32N2O2S
Molecular Weight 424.60
Synonyms K201
Introduction of 1038410-88-6 :

JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2]. In Vitro: JTV-519 (K201) inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201[2]. In Vivo: JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3].

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