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104075-48-1 | Atipamezole (hydrochloride)

Atipamezole (hydrochloride) NLT 98%

SKU : MC503759

CAS Number : 104075-48-1

Molecular Formula : C14H17ClN2 | Molecular Weight : 248.75

Synonyms : MPV-1248 hydrochloride

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Atipamezole (hydrochloride)
CAS Number 104075-48-1
MDL Number MFCD06407819
Molecular Formula C14H17ClN2
Molecular Weight 248.75
Synonyms MPV-1248 hydrochloride
Introduction of 104075-48-1 :

Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. IC50 & Target: Ki: 1.6 nM[1] In Vitro: The affinity of atipamezole for α2-adrenoceptors and its α21 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. In Vivo: Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].

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