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104632-25-9 | Pramipexole (dihydrochloride)

Pramipexole (dihydrochloride) NLT 98%

SKU : MC503972

CAS Number : 104632-25-9

Molecular Formula : C10H19Cl2N3S | Molecular Weight : 284.25

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Pramipexole (dihydrochloride)
CAS Number 104632-25-9
MDL Number MFCD00876894
Molecular Formula C10H19Cl2N3S
Molecular Weight 284.25
Introduction of 104632-25-9 :

Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. IC50 Value: 3.9 nM(D2S); 2.2 nM(D2L); 0.5 nM(D3); 5.1 nM(D4) Target: Dopamine Receptor Pramipexole dihydrochloride is a dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Pramipexole dihydrochloride exhibits negligable affinity for D1 and D5 receptors. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways. Pramipexole displays activity in the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS).

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