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1050480-30-2 | PhiKan 083 hydrochloride

PhiKan 083 hydrochloride NLT 98%

SKU : MC504230

CAS Number : 1050480-30-2

Molecular Formula : C16H19ClN2 | Molecular Weight : 274.79

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name PhiKan 083 hydrochloride
CAS Number 1050480-30-2
MDL Number MFCD07168924
Molecular Formula C16H19ClN2
Molecular Weight 274.79
Introduction of 1050480-30-2 :

PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. IC50 & Target: Kd: 167 μM (p53-Y220C)[1], 150 μM (p53Y220C, in Ln229 cells)[3] In Vitro: PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells[3].
PhiKan 083 slows down its thermal denaturation rate[2].
PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells[3].
PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W)[3].

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