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10540-29-1 | Tamoxifen

Tamoxifen NLT 98%

SKU : MC504407

CAS Number : 10540-29-1

Molecular Formula : C25H28ClNO | Molecular Weight : 393.95

Synonyms : ICI 47699;(Z)-Tamoxifen;trans-Tamoxifen

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name Tamoxifen
CAS Number 10540-29-1
MDL Number MFCD03423594
Molecular Formula C25H28ClNO
Molecular Weight 393.95
Synonyms ICI 47699;(Z)-Tamoxifen;trans-Tamoxifen
Introduction of 10540-29-1 :

Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis[4]. In Vitro: Tamoxifen (ICI 47699) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2]. In Vivo: The Tamoxifen-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3].

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