Tel: +86 (0)571 8102-5280 Email:
105431-72-9 | Linopirdine

Linopirdine NLT 98%

SKU : MC504414

CAS Number : 105431-72-9

Molecular Formula : C26H21N3O | Molecular Weight : 391.46

Synonyms : DuP 996

Quote Request
Purity NLT 98%
Storage at 20ºC 2 years

* The above information is for reference only.

* If the product has intellectual property rights, a license granted is must or contact us.

Chemical Name Linopirdine
CAS Number 105431-72-9
MDL Number MFCD00867216
Molecular Formula C26H21N3O
Molecular Weight 391.46
Synonyms DuP 996
Introduction of 105431-72-9 :

Linopirdine (DuP 996) is an orally active, selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor with an IC50 of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing drug, increases acetylcholine release in rat brain tissue[1][2][3]. IC50 & Target: IC50: 2.4 μM (M-type K+ current)[1] In Vitro: Linopirdine (DuP 996) inhibits IC (measured as a medium afterhyperpolarization tail current, ImAHP) with an IC50 of 16.3 μM. Linopirdine (100 μM) weakly inhibits the K+ leak current, IL, the transient outward current, IA, the delayed rectifier, IK, and the slow component of IAHP, by 28, 37, 36 and 52 percent, respectively. The mixed Na+/K+ inward rectifying current, IQ, is essentially unaffected by Linopirdine (IC50>300 μM)[1].
Linopirdine acts as an agonist of TRPV1 (transient receptor potential vanilloid type 1)[3].
In Vivo: Linopirdine (DuP 996; i.v.; 0.1-6 mg/kg; increasing doses) transiently (10-15 min) and dose-dependently increases MAP by up to 15%[2].

Related Products