ML-9 NLT 98%
SKU : MC504493
CAS Number : 105637-50-1
Molecular Formula : C15H18Cl2N2O2S | Molecular Weight : 361.29
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | ML-9 |
|---|---|
| CAS Number | 105637-50-1 |
| MDL Number | MFCD00065525 |
| Molecular Formula | C15H18Cl2N2O2S |
| Molecular Weight | 361.29 |
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
In Vitro: ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2].
ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2].
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