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105637-50-1 | ML-9

ML-9 NLT 98%

SKU : MC504493

CAS Number : 105637-50-1

Molecular Formula : C15H18Cl2N2O2S | Molecular Weight : 361.29

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name ML-9
CAS Number 105637-50-1
MDL Number MFCD00065525
Molecular Formula C15H18Cl2N2O2S
Molecular Weight 361.29
Introduction of 105637-50-1 :

ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
In Vitro: ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2].
ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2].

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