Product Number : MC504498
CAS Number : 105650-23-5
Molecular Formula : C13H12N4 | Molecular Weight : 224.26
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
MolCore specializes in manufacturing high-purity CAS No.105650-23-5, PhIP with the molecular formula C13H12N4 and molecular weight 224.26 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. |
* The above information is for reference only.
Chemical Name | PhIP |
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CAS Number | 105650-23-5 |
MDL Number | MFCD00210745 |
Molecular Formula | C13H12N4 |
Molecular Weight | 224.26 |
PhIP is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2]. In Vitro: PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer[2]. In Vivo: In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents[1].
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