1094048-77-7

I-OMe-Tyrphostin AG 538 NLT 98%

Name: I-OMe-Tyrphostin AG 538
Brand: Molcore
SKU: MC505967
Rating: 95 (32 reviews)

SKU : MC505967

CAS Number : 1094048-77-7

Molecular Formula : C17H12INO5 | Molecular Weight : 437.19

Synonyms : I-OMe-AG 538

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Purity	NLT 98%
Storage	at 20ºC 2 years

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Chemical Name	I-OMe-Tyrphostin AG 538
CAS Number	1094048-77-7
MDL Number	MFCD03453582
Molecular Formula	C17H12INO5
Molecular Weight	437.19
Synonyms	I-OMe-AG 538

Introduction of 1094048-77-7 :

I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀ of 1 µM^[1]. IC50 & Target: IC50: 1 µM (PI5P4Kα)^[1] In Vitro: I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium^[1].
I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk^[1].

1094048-77-7

I-OMe-Tyrphostin AG 538 NLT 98%

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