SKU : MC506141
CAS Number : 109946-35-2
Molecular Formula : C41H66O13 | Molecular Weight : 766.95
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Tautomycin |
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CAS Number | 109946-35-2 |
MDL Number | MFCD00236438 |
Molecular Formula | C41H66O13 |
Molecular Weight | 766.95 |
Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2]. IC50 & Target: Kiapp: 0.16 nM (PP1), 0.4 nM (PP2A)[1]. In Vitro: MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].
NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].
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