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112648-68-7 | U-73122

U-73122 NLT 98%

SKU : MC507182

CAS Number : 112648-68-7

Molecular Formula : C29H40N2O3 | Molecular Weight : 464.64

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name U-73122
CAS Number 112648-68-7
MDL Number MFCD00893825
Molecular Formula C29H40N2O3
Molecular Weight 464.64
Introduction of 112648-68-7 :

U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC. In Vitro: U-73122 potently inhibits receptor-coupled activation of PLC in membranes isolated from PMNs[1]. U-73122 inhibits N-formyl-methionyl-leucyl-phenylalanine-induced aggregation of human polymorphonuclear neutrophils (PMN) and the associated production of IP3 and diacyglycerol[2]. U-73122 markedly inhibits inositol phosphate release elicited by either oxotremorine-M or guanosine-5'-O-(3-thiotriphosphate) than that induced by added Ca2+ in digitonin-permeabilized cells[3]. In Vivo: U73122 significantly attenuates TNF-α mRNA expression, has no effect on sham animals, but significantly increases heart work and rate of contraction and relaxation without affecting heart rate in endotoxemic mice[4]. U73122 (400 nM/μL) significantly reduces total lordosis durations, compared to vehicle infusions to the VTA, of oestradiol and progesterone-primed hamsters. VTA infusions of U73122 do not alter motor behaviour of hamsters in the activity monitor, but there is a significant effect of muscimol to decrease total number of beam breaks compared to hamsters administered SKF38393[5].

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