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113170-55-1 | L-Ascorbic acid 2-phosphate (magnesium)

L-Ascorbic acid 2-phosphate (magnesium) NLT 98%

SKU : MC507380

CAS Number : 113170-55-1

Molecular Formula : C6H7MgO9P | Molecular Weight : 278.39

Synonyms : 2-Phospho-L-ascorbic acid (magnesium)

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Purity NLT 98%
Storage at 20ºC 2 years

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Chemical Name L-Ascorbic acid 2-phosphate (magnesium)
CAS Number 113170-55-1
Molecular Formula C6H7MgO9P
Molecular Weight 278.39
Synonyms 2-Phospho-L-ascorbic acid (magnesium)
Introduction of 113170-55-1 :

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3]. IC50 & Target: IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3] In Vitro: L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3].

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