SKU : MC507503
CAS Number : 1135280-28-2
Molecular Formula : C24H28ClN2O7PS | Molecular Weight : 554.98
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | KN-92 (phosphate) |
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CAS Number | 1135280-28-2 |
Molecular Formula | C24H28ClN2O7PS |
Molecular Weight | 554.98 |
KN-92 phosphate is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). IC50 value: Target: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.
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