D159687 NLT 98%
SKU : MC508254
CAS Number : 1155877-97-6
Molecular Formula : C21H19ClN2O2 | Molecular Weight : 366.84
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | D159687 |
|---|---|
| CAS Number | 1155877-97-6 |
| MDL Number | MFCD22665725 |
| Molecular Formula | C21H19ClN2O2 |
| Molecular Weight | 366.84 |
D159687 is a selective PDE4D inhibitor[1]. IC50 & Target: PDE4D[1] In Vitro: D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. In Vivo: D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2].
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