SKU : MC511611
CAS Number : 1208315-24-5
Molecular Formula : C24H22N4O3 | Molecular Weight : 414.46
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
Chemical Name | N6022 |
---|---|
CAS Number | 1208315-24-5 |
MDL Number | MFCD22123247 |
Molecular Formula | C24H22N4O3 |
Molecular Weight | 414.46 |
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM. IC50 & Target: IC50: 8 nM (GSNOR)[2] In Vitro: N6022 shows concentration-dependent binding to rat plasma proteins. N6022 has more effect on ATP at lower drug concentrations (20 μM) than on GSH[1]. N6022 binds in the GSNO substrate binding pocket like a competitive inhibitor with an IC50 of 8 nM and a Ki of 2.5 nM. N6022 is uncompetitive with cofactors NAD+ and NADH[2]. In Vivo: N6022 (50 mg/kg)-treated rats show a slight increase in the incidence of granulomas. In serum, N6022 remains in solution up to 5 mg/mL[1].
© Copyright 2015-2024 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.