JZL195 NLT 98%

JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC₅₀s of 2 and 4 nM, respectively^[1]. IC50 & Target: IC50: 2 nM (FAAH), 4 nM (MAGL)^[1] In Vitro: JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC₅₀ values of 13 and 19 nM, respectively)^[1].
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC₅₀ values in the range of ≈10-100 nM based on competitive ABPP assays^[1]. In Vivo: JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay^[1].