122955-13-9

XE 991 dihydrochloride NLT 98%

Name: XE 991 dihydrochloride
Brand: Molcore
SKU: MC513150
Rating: 97 (26 reviews)

SKU : MC513150

CAS Number : 122955-13-9

Molecular Formula : C26H22Cl2N2O | Molecular Weight : 449.37

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Purity	NLT 98%
Storage	at 20ºC 2 years

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Chemical Name	XE 991 dihydrochloride
CAS Number	122955-13-9
MDL Number	MFCD09055426
Molecular Formula	C26H22Cl2N2O
Molecular Weight	449.37

Introduction of 122955-13-9 :

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively^[1]. IC50 & Target: IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)^[1] In Vitro: XE 991 dihydrochloride possesses an EC₅₀ of 490 nM for enhancement of [³H]ACh release from rat brain slices, and shows good in vivo potency and duration of action^[2].

122955-13-9

XE 991 dihydrochloride NLT 98%

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