SKU : MC513161
CAS Number : 1229652-21-4
Molecular Formula : C24H19BFNO5S | Molecular Weight : 463.29
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | HA130 |
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CAS Number | 1229652-21-4 |
MDL Number | MFCD20926343 |
Molecular Formula | C24H19BFNO5S |
Molecular Weight | 463.29 |
HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. In Vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1]. In Vivo: HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].
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