SKU : MC514462
CAS Number : 125317-39-7
Molecular Formula : C53H66N4O20 | Molecular Weight : 1079.11
Synonyms : KW-2307;Nor-5'-anhydrovinblastine ditartrate
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Vinorelbine (ditartrate) |
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CAS Number | 125317-39-7 |
MDL Number | MFCD03613607 |
Molecular Formula | C53H66N4O20 |
Molecular Weight | 1079.11 |
Synonyms | KW-2307;Nor-5'-anhydrovinblastine ditartrate |
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. In Vitro: Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2]. In Vivo: After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].
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