KT5823 NLT 98%
SKU : MC515570
CAS Number : 126643-37-6
Molecular Formula : C29H25N3O5 | Molecular Weight : 495.53
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | KT5823 |
|---|---|
| CAS Number | 126643-37-6 |
| MDL Number | MFCD09878278 |
| Molecular Formula | C29H25N3O5 |
| Molecular Weight | 495.53 |
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3]. IC50 & Target: Ki: 0.23 μM (PKG); 10 μM (PKG); 4 μM (PKG) (KT5823)[1]
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