SKU : MC515881
CAS Number : 127308-82-1
Molecular Formula : C27H29NO3 | Molecular Weight : 415.52
Synonyms : UK-76654
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Zamifenacin |
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CAS Number | 127308-82-1 |
MDL Number | MFCD00867678 |
Molecular Formula | C27H29NO3 |
Molecular Weight | 415.52 |
Synonyms | UK-76654 |
Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome[1]. IC50 & Target: Muscarinic M3 receptor[1] In Vivo: Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and Cmax (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg)[2].
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].
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