SKU : MC516986
CAS Number : 13080-21-2
Molecular Formula : C8H8N4S | Molecular Weight : 192.24
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | HPi1 |
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CAS Number | 13080-21-2 |
MDL Number | MFCD00457014 |
Molecular Formula | C8H8N4S |
Molecular Weight | 192.24 |
HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1]. IC50 & Target: IC50: 0.24 μM (Helicobacter pylori)[1]
MIC: 0.08-0.16 μg/mL (Helicobacter pylori)[1] In Vitro: The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL)[1].
HPi1 has some activity against the Bacteroides species, but at concentrations at least 18-fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL[1].
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T1/2 of 1.3 hours) and the ability to passively permeate membranes[1]. In Vivo: HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day[1].
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